CFDA 93.866: Aging Research
NIA's primary CFDA for research on aging, Alzheimer's disease, and Alzheimer's-related dementias (AD/ADRD). Funding has expanded substantially due to the Alzheimer's Accountability Act bypass-budget process.
What this CFDA funds
Basic biology of aging research, Alzheimer's disease and AD/ADRD studies, geriatrics and clinical care research, behavioral and social research on aging, training programs (T32, F-series, K-series), and Alzheimer's Disease Research Centers (ADRCs). Recent priorities: precision medicine for AD, dementia disparities, caregiver research, and aging biomarkers.
What winning applicants look like
AAU research universities, NIA-designated ADRC institutions, and academic medical centers with strong geriatrics + neurology departments. The bypass-budget for Alzheimer's research means NIA success rates have been higher than NIH average — particularly for AD/ADRD-focused proposals.
Common pitfalls + things to know
Distinguish between aging-as-context (an R01 about hypertension in older adults) and aging-as-mechanism (an R01 about cellular senescence). NIA prioritizes the latter for basic biology mechanisms. AD/ADRD-tagged proposals route to AD-specific review panels with separate paylines.
Open NOFOs under CFDA 93.866 6 active
Currently posted NOFOs and assistance listings tagged with CFDA 93.866, soonest deadline first. Refreshed Jun 14, 2026.
- Claude D. Pepper Older Americans Independence CentersNational Institutes of Health · grants.gov · Closes: Rolling / no posted deadline
- Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed)National Institutes of Health · grants.gov · Closes: Rolling / no posted deadline
- Improving Chronic Conditions Through Inexpensive InterventionsNational Institutes of Health · grants.gov · Closes: Rolling / no posted deadline
- Controlled Clinical Trials on Long-Term Effects of Nutritional Interventions on the Progression of Risk Factors for Age-Related Chronic Conditions Over the Life Span and Their Age of OnsetNational Institutes of Health · grants.gov · Closes: Rolling / no posted deadline
- Resource-Related Research Projects Cooperative Agreements in Aging and/or Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) ResearchNational Institutes of Health · grants.gov · Closes: Rolling / no posted deadline
- Research Project Cooperative Agreements in Aging and/or Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD) ResearchNational Institutes of Health · grants.gov · Closes: Rolling / no posted deadline
Related CFDAs to also explore
- CFDA 93.310 — Trans-NIH Research Support
- CFDA 93.853 — Extramural Research Programs in Neurosciences and Neurological Disorders
- CFDA 93.398 — Cancer Research
Reference guides
Evergreen explainers for nonprofit grant offices and federal grant seekers.
- Federal Grants for Nonprofits: A 2026 Guide for 501(c)(3) Organizations — CFDA prefixes, applicant-type code 12, forecasts, the deadline trap.
- The Grants.gov Search Guide: How to Actually Find Federal Grants in 2026 — practical filter walkthrough, native-vs-paid tool comparison.
- → All Grant Wire articles
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Always verify in the official source. CFDA program details, eligibility, and award ranges change with each annual NOFO cycle. Confirm at sam.gov/content/assistance-listings or the agency's program office before you build an application strategy. This page is editorial reference, not an official agency notice.