CFDA / Assistance Listing · Reference

CFDA 93.788: Opioid Affected Youth and Families Initiative

Targeted federal funding for community-level interventions in opioid-affected populations. Heavily competitive but high mission-fit for nonprofits already serving rural and underserved communities.

Agency

HRSA (HHS)

Typical award

$300,000 – $1,000,000 per year, typically over 3-4 years

Eligible applicants

501(c)(3) nonprofits
Federally Qualified Health Centers (FQHCs) and look-alikes
Public and private IHEs (medical schools, schools of social work)
State, county, city, and tribal governments
Public and tribal-run health systems

What this CFDA funds

Multi-year cooperative agreements supporting OUD/SUD prevention, treatment access expansion, peer-recovery infrastructure, and workforce training in HRSA-designated rural and underserved areas. Many awards target the rural communities opioid response (RCORP) framework: Planning year, Implementation 3 years.

What winning applicants look like

FQHC consortia, regional behavioral-health collaboratives, and rural-health-network nonprofits with documented community-engagement processes. Past performance on similar HRSA awards (RCORP, BHWET) is a major scoring lift. State-level strategic alignment letters help significantly.

Common pitfalls + things to know

HRSA NOFOs require a logic model with specified evaluation metrics — generic logic models are rejected. Population definitions must match HRSA's underserved-community designation (the HPSA or MUA shapefiles). Indirect-rate caps in the NOFO are common (often 10% MTDC). Cost-sharing is sometimes required.

Open NOFOs under CFDA 93.788 2 active

Currently posted NOFOs and assistance listings tagged with CFDA 93.788, soonest deadline first. Refreshed Jun 14, 2026.

Emergency Department Alternatives to Opioids
Substance Abuse and Mental Health Services Adminis · grants.gov · Closes: Rolling / no posted deadline
Tribal Opioid Response
Substance Abuse and Mental Health Services Adminis · grants.gov · Closes: Rolling / no posted deadline

Related CFDAs to also explore

CFDA 93.243 — SAMHSA Mental Health Services Projects
CFDA 93.359 — HRSA NEPQR (workforce)
CFDA 93.150 — Projects for Assistance in Transition from Homelessness

Reference guides

Evergreen explainers for nonprofit grant offices and federal grant seekers.

Federal Grants for Nonprofits: A 2026 Guide for 501(c)(3) Organizations — CFDA prefixes, applicant-type code 12, forecasts, the deadline trap.
The Grants.gov Search Guide: How to Actually Find Federal Grants in 2026 — practical filter walkthrough, native-vs-paid tool comparison.
→ All Grant Wire articles

Audiences who use this CFDA

If you fall into one of these audience groups, the audience guide gives you the broader picture of all federal funding streams you qualify for — not just CFDA 93.788.

Community Health Centers and FQHCs

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Always verify in the official source. CFDA program details, eligibility, and award ranges change with each annual NOFO cycle. Confirm at sam.gov/content/assistance-listings or the agency's program office before you build an application strategy. This page is editorial reference, not an official agency notice.